| Research area | Chemistry and Materials Science and Technology |
| Title | Photocontrol of Endogenous Glycine Receptors In Vivo |
| Publication Type | Journal Article |
| Publication year | 2020 |
| Authors | Gomila, AMJ, Rustler, K, Maleeva, G, Nin-Hil, A, Wutz, D, Bautista-Barrufet, A, Rovira, X, Bosch, M, Mukhametova, E, Petukhova, E, Ponomareva, D, Mukhamedyarov, M, Peiretti, F, Alfonso-Prieto, M, Rovira, C, Koenig, B, Bregestovski, P, Gorostiza, P |
| Journal | CELL CHEMICAL BIOLOGY |
| Volume | 27 |
| Number | 11 |
| Pages | 1425+ |
| Type of Article | Article |
| Abstract | Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies. |
| DOI | 10.1016/j.chembiol.2020.08.005 |
