Sergi Picó/Lucía Romero et al (ELEM Biotech/Ci2B) — Atrial Electromechanical Modeling for In Silico Assessment of Atrial Fibrillation Therapies
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Check this Success Story at our LinkedIn: Atrial Electromechanical Modeling for In Silico Assessment of Atrial Fibrillation Therapies
💡A RES success story about simulating cardiac functions💡
📋 "Atrial Electromechanical Modeling for In Silico Assessment of Atrial Fibrillation Therapies" developed by Sergi Picó Cabiró, Alberto Zingaro, Eva Casoni and Mariano Vazquez from ELEM Biotech, in collaboration with Violeta Puche García, Francisco Javier Saiz Rodriguez and Lucía Romero Pérez from Ci2B - Center for Research and Innovation in Bioengineering
Heart's atria are the two upper chambers of the heart and play a central role in cardiac function. They are also involved in cardiac conditions like atrial fibrillation, so a high fidelity fidelity computational model that captures the complex electromechanical behavior of the human atria is key to understand and treat these disorders.
The team developed a model combining detailed electrophysiological dynamics with mechanical features of atrial tissue, allowing to simulate the full cycle of atrial function: reservoir, conduit, and booster phases. It accounts for both anatomical and electrical heterogeneity and it is coupled to a simplified circulatory model to reflect pressure and flow dynamics across the heart.
🖥️ Thanks to RES supercomputer hashtagMareNostrum5 from Barcelona Supercomputing Center, they used the Alya multiphysics simulation code to carry out large-scale simulations with high spatial and temporal resolution. The model has been calibrated and validated against literature clinical data, including key physiological biomarkers like atrial volumes and ejection fractions.
One of the main goals is to use this modeling framework to explore treatment strategies in silico for atrial fibrillation, such as antiarrhythmic drugs and catheter ablation. By simulating how individual patients might respond to specific interventions, this approach moves us closer to truly personalized treatment planning in cardiology.
📷 The image shows a simulation of the electromechanical activity of the atria and pv loops
This project is a collaboration between Ci2B - Center for Research and Innovation in Bioengineering, Barcelona Supercomputing Center and ELEM Biotech
📋 "Atrial Electromechanical Modeling for In Silico Assessment of Atrial Fibrillation Therapies" developed by Sergi Picó Cabiró, Alberto Zingaro, Eva Casoni and Mariano Vazquez from ELEM Biotech, in collaboration with Violeta Puche García, Francisco Javier Saiz Rodriguez and Lucía Romero Pérez from Ci2B - Center for Research and Innovation in Bioengineering
Heart's atria are the two upper chambers of the heart and play a central role in cardiac function. They are also involved in cardiac conditions like atrial fibrillation, so a high fidelity fidelity computational model that captures the complex electromechanical behavior of the human atria is key to understand and treat these disorders.
The team developed a model combining detailed electrophysiological dynamics with mechanical features of atrial tissue, allowing to simulate the full cycle of atrial function: reservoir, conduit, and booster phases. It accounts for both anatomical and electrical heterogeneity and it is coupled to a simplified circulatory model to reflect pressure and flow dynamics across the heart.
🖥️ Thanks to RES supercomputer hashtagMareNostrum5 from Barcelona Supercomputing Center, they used the Alya multiphysics simulation code to carry out large-scale simulations with high spatial and temporal resolution. The model has been calibrated and validated against literature clinical data, including key physiological biomarkers like atrial volumes and ejection fractions.
One of the main goals is to use this modeling framework to explore treatment strategies in silico for atrial fibrillation, such as antiarrhythmic drugs and catheter ablation. By simulating how individual patients might respond to specific interventions, this approach moves us closer to truly personalized treatment planning in cardiology.
📷 The image shows a simulation of the electromechanical activity of the atria and pv loops
This project is a collaboration between Ci2B - Center for Research and Innovation in Bioengineering, Barcelona Supercomputing Center and ELEM Biotech